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Thursday Night Football: Miami Dolphins vs. Buffalo Bills

Posted Sept. 18, 2025, 2:52 p.m. by Michael Shannon 1 min read
Thursday Night Football: Miami Dolphins vs. Buffalo Bills

Tonight’s NFL matchup brings the Buffalo Bills back home to face the Miami Dolphins under the bright lights of Thursday Night Football, and there’s no shortage of storylines heading into kickoff. Buffalo is 2-0, rolling into this one with confidence after a strong start, while Miami is trying to avoid the dreaded 0-3 hole that could bury them early in the AFC East standings. On paper, it looks like Buffalo has the upper hand and they’ve beaten Miami in six straight contests, but divisional games always carry a little extra weight, and desperation can make an underdog dangerous.

The Bills’ attack continues to flow through Josh Allen, who remains one of the most difficult quarterbacks to defend in the league. His arm strength and ability to extend plays with his legs create matchup nightmares, especially against a Miami defense that has been vulnerable to big plays. Running back James Cook adds balance, and if Buffalo’s ground game finds success, it opens up everything else offensively. On the other side, Miami’s health is a concern. They’re already missing Darren Waller, Storm Duck, and Ifeatu Melifonwu, while star wideout Jaylen Waddle is questionable. Without Waddle, Miami’s offense leans heavily on Tyreek Hill, which could allow Buffalo to key in defensively.

The injury report isn’t perfect for Buffalo either. Key defenders like Ed Oliver and Matt Milano are sidelined, but the Bills have the depth to withstand those losses, especially with a raucous home crowd behind them. The critical matchups will be whether Miami’s secondary can slow down Allen, whether Cook can exploit a shaky run defense, and whether the Dolphins’ offense can stay efficient without relying solely on explosive plays.

This is exactly where ATSwins comes in. Our AI-powered models have simulated tonight’s matchup thousands of times, weighing the impact of injuries, pace of play, and game flow. Instead of guessing, you can see the actual win probabilities, point spread projections, and totals derived from real data, all available now on the ATSwins Predictions Page. If you want to know whether Buffalo’s dominance continues, or if Miami has a real shot at pulling off an upset, our full read has the answers.

And if you’re looking to get even more specific, check out the ATSwins Player Prop Projections. From Josh Allen’s passing yards to James Cook’s rushing totals and Tyreek Hill’s receiving line, our AI models break down which props have value and which ones to avoid. For many bettors, props are where the biggest edges are, and our projections are built to update in real time with lineup changes and injury confirmations.

Tonight’s game isn’t just a battle for early AFC East positioning — it’s also a perfect example of why relying on hard data matters more than gut feeling. Buffalo has the momentum, Miami has the desperation, and the numbers tell the full story. Don’t just watch the game, watch it with the edge of knowing where the probabilities lie.

👉 Head to the ATSwins Predictions Page for the complete breakdown of tonight’s Bills vs Dolphins matchup.

👉 Explore the Player Prop Projections to find the best individual edges on the board before kickoff.












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