Giants at Padres Prediction: Odds, expert picks, starting pitchers, betting trends and stats for August 21

It's Thursday, August 21 and the Giants (61-66) are in San Diego to take on the Padres (71-56).

Justin Verlander is slated to take the mound for San Francisco against Dylan Cease for San Diego.San Diego goes for the series win after a 8-1 victory on Wednesday to follow up a 5-1 win.

The Padres' two wins snapped a four-game losing skid the team had going whereas the Giants are 2-9 over the last 11 games and 2-2 in the past four.Let's dive into the matchup and find a sweat or two.

Weve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.Game details & how to watch Giants at PadresDate: Thursday, August 21, 2025Time: 4:10PM ESTSite: Petco ParkCity: San Diego, CANetwork/Streaming: NBCSBA, SDPANever miss a second of the action and stay up-to-date with all the latest team stats and player news.

Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.Odds for the Giants at the PadresThe latest odds as of Thursday:Moneyline: Giants (+145), Padres (-173)Spread: Padres -1.5Total: 8.0 runsProbable starting pitchers for Giants at PadresPitching matchup for August 21, 2025: Justin Verlander vs.

Dylan CeaseGiants: Justin Verlander, (1-9, 4.23 ERA)Last outing: 0.00 ERA, 0 Earned Runs Allowed, 2 Hits Allowed, 0 Walks, and 8 StrikeoutsPadres: Dylan Cease, (5-11, 4.61 ERA)Last outing: 8.10 ERA, 3 Earned Runs Allowed, 2 Hits Allowed, 6 Walks, and 2 StrikeoutsRotoworld still has you covered with all the latest MLB player news for all 30 teams.

Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!Expert picks & predictions for tonights game between the Giants and the Padres Rotoworld Best BetPlease bet responsibly.

If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.Here are the best bets our model is projecting for Thursdays game between the Giants and the Padres:Moneyline: NBC Sports Bet is recommending a play on the San Diego Padres on the Moneyline.Spread: NBC Sports Bet is leaning towards a play ATS on the San Francisco Giants at +1.5.Total: NBC Sports Bet is staying away from a play on the Game Total of 8.0.Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.Top betting trends & insights to know ahead of Giants at PadresSan Diego is 9-3 versus San Francisco this seasonThe Giants are 2-9 in the last 11 gamesThe Padres are 2-4 in the last 6 gamesThe Padres have won 4 of their last 5 home games against teams with losing recordsThe Under is 48-37-5 in the Padres' matchups against National League teams this seasonThe Giants have failed to cover the Run Line in 4 of their last 5 road games against the PadresIf youre looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!Follow our experts on socials to keep up with all the latest content from the staff:Jay Croucher (@croucherJD)Drew Dinsick (@whale_capper)Vaughn Dalzell (@VmoneySports)Trysta Krick (@Trysta_Krick).

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