NFL Betting 2025: Best RB anytime touchdown props to target in Week 1

Rookie TreVeyon Henderson is set up to thrive against the Raiders : Henderson brings the ability of a true three-down back to the Patriots' offense and he's already showing it in the preseason.

Jerome Ford is a good value bet against the Bengals : Ford, who may have a prominent role in the Browns' backfield early on, showcased some of his best work to close out 2024, including against the Bengals in Week 16.

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These are some of the best anytime touchdown props to target for running backs in Week 1 of the 2025 NFL season.

TreVeyon Henderson , New England Patriots (+155) Click to explore PFF's new Player Props Tool! Were just one week into preseason games, and its already become readily apparent that rookie TreVeyon Henderson is going to be a focal point in New England.

He brings the ability of a true three-down back to the offense and is a home-run threat in the return game.

That versatility will give the first-year back ample opportunities to produce.

Hendersons first test comes in the form of a Raiders defense that finished the 2024 season ranked in the top 12 in PFF run-defense grade (69.9).

However, 2025 may not shape up as cleanly after Las Vegas watched on as its three highest-graded run defenders Tre'von Moehrig (87.5), Robert Spillane (87.3) and Christian Wilkins (80.2) departed this offseason.

Without them in the mix, Henderson faces a plus matchup that he can exploit.

Click to explore PFF's new Player Props Tool! With Rhamondre Stevenson still in the backfield, Henderson's touches may be limited as he works to prove himself at the NFL level.

He excelled while splitting the workload at Ohio State last season, totaling 11 touchdowns, including five scores across his final four games against strong opponents in Tennessee , Oregon and Texas .

Jerome Ford , Cleveland Browns (+265) Click to explore PFF's new Player Props Tool! The Browns' backfield situation continues to develop, and the outcome may have serious implications, as the offense will likely need to lean on the ground game.

Second-round back Quinshon Judkins remains unsigned and could begin the year on the commissioners exempt list, so the expectation is that Jerome Ford and rookie Dylan Sampson will carry the load for now.

Although Fords usage was spotty last season following Nick Chubb s return from injury, he was clearly the most effective runner, finishing with the highest PFF rushing grade (82.3) among Browns backs.

He showcased some of his best work to close out 2024, when he found the endzone in two of his last three games.

In Week 16, he gashed the Bengals for 92 yards and a score on just 11 carries.

Click to explore PFF's new Player Props Tool! The Bengals invested in their front-seven with a pair of early draft picks, but questions remain if that will solve their issues with fitting the run.

Cincinnati ranked 28th in EPA allowed per rush and 23rd in touchdowns allowed to running backs in 2024.

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