College Football Betting Odds Week 5: Picks Against the Spread for Top 25 Schedule

The Alabama Crimson Tide have not been a home underdog since 2007.

Jalen Milroe and Co.

are the slightest of underdogs for Saturday's clash of the SEC titans with the Georgia Bulldogs.

Georgia is understandably the favorite as the higher-ranked team, but it has had much success against Alabama under Kirby Smart.

Of course, Nick Saban is no longer on the Alabama sidelines and that could play a role in how the game goes down.

Kalen DeBoer took Washington to the National Championship last season, but this is his first big test in the SEC.

While all eyes will be on Tuscaloosa in Week 5, there are a handful of other notable games within the Top 25, including one in the Big 12 that has the feel of a playoff elimination game.

Odds via DraftKings Sportsbook.

Friday, September 27 Virginia Tech at No.

7 Miami (-17.5) (7:30 p.m.

ET, ESPN) Saturday, September 28 Kentucky at No.

6 Ole Miss (-15.5) (Noon ET, ABC) Minnesota at No.

12 Michigan (-10) (Noon ET, Fox) No.

20 Oklahoma State at No.

23 Kansas State (-5) (Noon ET, ESPN) No.

22 BYU at Baylor (-3) (Noon ET, FS1) Wisconsin at No.

13 USC (-15.5) (3:30 p.m.

ET, CBS) No.

15 Louisville at No.

16 Notre Dame (-7) (3:30 p.m.

ET, Peacock) Arkansas vs.

No.

24 Texas A&M (-5.5) (3:30 p.m.

ET, ESPN) No.

21 Oklahoma at Auburn (-1) (3:40 p.m.

ET, ABC) Mississippi State at No.

1 Texas (-38) (4:15 p.m.

ET, SEC Network) No.

3 Ohio State (-23.5) at Michigan State (7 p.m.

ET, Peacock) Stanford at No.

17 Clemson (-21.5) (7 p.m.

ET, ESPN) No.

18 Iowa State (-16) at Houston (7 p.m.

ET, FS1) No.

2 Georgia (-1) at No.

4 Alabama (7:30 p.m.

ET, ABC) No.

19 Illinois at No.

9 Penn State (-18) (7:30 p.m.

ET, NBC) South Alabama at No.

14 LSU (-20.5) (7:45 p.m.

ET, SEC Network) Washington State at No.

25 Boise State (-6.5) (10 p.m.

ET, FS1) Arizona at No.

10 Utah (-8) (180:15 p.m.

ET, ESPN) No.

8 Oregon (-25.5) at UCLA (10:30 p.m.

ET, Fox) Alabama has had the upper hand in the rivalry with Georgia, but UGA owns the most recent win in a National Championship over the Tide.

Georgia is 1-5 straight up against Alabama since 2018.

Three of the games in that span were decided by one possession, but a handful of them have not been close.

The Bulldogs are a slight one-point favorite as of Friday morning and that might change depending on how much money comes in on Alabama.

Alabama has some impressive score lines in its favor so far this season, but it has not shown its breakaway speed until the second half.

In Week 2, the Tide needed a fourth quarter surge to beat the South Florida Bulls by 20 points.

Two weeks ago, it took Bama until the second half to completely pull away from a Wisconsin Badgers side that lost its starting quarterback in the first quarter.

Georgia has questions about itself after barely surviving an upset bid from the Kentucky Wildcats two weeks ago.

The one-point road win can be considered more of a slight slip-up compared to what UGA's overall quality this season will be.

Georgia certainly comes in with motivation to prove it is still the top dog in the SEC, which is something it will have to prove twice more in conference play against the Texas Longhorns and Ole Miss Rebels.

UGA's defense could be the ultimate difference-maker in Tuscaloosa.

The Bulldogs allowed 18 points in their first three games, and if they can contain Milroe and limit the Tide to field goals, they should come away with a victory.

Saturday's clash in Manhattan, Kansas flipped from a potential Big 12 title showcase to a playoff survival game in the span of a week.

The Oklahoma State Cowboys fell flat at home against the Utah Utes in Week 4, while the Kansas State Wildcats stumbled on the road against the BYU Cougars.

Both teams are clearly in a second tier of the Big 12 behind Utah going into Week 5, and given how many at-large spots could be handed out to the SEC and Big Ten, it is vital that both teams win this game.

Kansas State is more trustworthy at the moment because at least it has a true offensive identity behind quarterback Avery Johnson and it is typically strong at home.

OK State running back Ollie Gordon has been terrible this season.

He is averaging 3.5 yards per carry in 2024.

He averaged 6.1 yards per attempt last year.

The Cowboys failed to establish any offensive rhythm against Utah and that could haunt them again in Manhattan.

K-State has also been a proven commodity in conference play for bettors.

The Wildcats are 31-15-1 against the spread under Chris Klieman in Big 12 games.

That trend came into play two weeks ago in the 31-7 win over the Arizona Wildcats.

It will not matter who starts at quarterback for the Texas Longhorns on Saturday.

Quinn Ewers is listed as questionable, but it would be smart to rest him with the October 12 clash against the Oklahoma Sooners on the horizon.

Arch Manning should lead the offense past the Mississippi State Bulldogs, who have made a strong case to be not just the worst team in the SEC, but the worst power-conference squad.

The Bulldogs lost at home to the Toledo Rockets two weeks ago and failed to compete with the Florida Gators in their SEC opener last week.

On top of all that misery, quarterback Blake Shapen suffered a season-ending shoulder injury in the loss to Florida.

Texas held three of its four opponents to single-digit point totals and covered the spread in each of its first four games.

The 38-point spread may seem high, but an argument could be made that it needs to be bigger in Texas' favor given how poor Mississippi State has looked.

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