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San Francisco 49ers Injury Report
| Date Reported | Player | POS | Status / Description |
|---|---|---|---|
| 2026-09-24 | |||
| Romello Height | DE | Questionable | |
| Nick Bosa | DE | Questionable | |
| Mike Evans | WR | Questionable | |
| 2026-09-23 | C.J. West | DT | Injured Reserve |
| 2026-09-21 | |||
| James Thompson Jr. | DT | Doubtful | |
| Demarcus Robinson | WR | Out | |
| Brandon Aiyuk | WR | Out | |
| 2026-09-20 | Jack Jones | CB | Questionable |
| 2026-09-19 | De'Zhaun Stribling | WR | Injured Reserve |
| 2026-09-16 | Jake Tonges | TE | Injured Reserve |
| 2026-09-10 | Alfred Collins | DT | Injured Reserve |
| 2026-09-08 | |||
| Nate Hobbs | CB | Injured Reserve | |
| Mykel Williams | DE | Out | |
| 2026-09-07 | Sam Okuayinonu | DT | Injured Reserve |
| 2026-09-01 | Nick Martin | LB | Injured Reserve |
| 2026-08-31 | |||
| Nick Zakelj | OT | Injured Reserve | |
| Brett Toth | C | Injured Reserve | |
| Austen Pleasants | OT | Injured Reserve | |
| 2026-08-30 | |||
| Christian Kirk | WR | Injured Reserve | |
| Isaac Guerendo | RB | Out | |
| 2026-08-13 | Ricky Pearsall | WR | Injured Reserve |
| 2026-08-03 | Mikail Kamara | DE | Injured Reserve |
| 2026-07-30 | Andrew Farmer II | DE | Injured Reserve |
| 2026-05-28 | Darrick Forrest | S | Injured Reserve |