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San Francisco 49ers Injury Report
| Date Reported | Player | POS | Status / Description |
|---|---|---|---|
| 2026-10-28 | |||
| Christian McCaffrey | RB | McCaffrey is dealing with a mild hamstring strain rather than a quadriceps injury, and the 49ers believe he'll be ready following the team's Week 8 bye, David Lombardi of SF Standard reports. | |
| Mike Evans | WR | Evans (Achilles) is expected to return after San Francisco's Week 8 bye, David Lombardi of SF Standard reports. | |
| De'Zhaun Stribling | WR | Stribling (ankle) remains on track to return in December, David Lombardi of SFStandard.com reports. | |
| Demarcus Robinson | WR | 49ers coach Kyle Shanahan reiterated Monday that Robinson (ankle) has a chance to return following the team's Week 8 bye, David Lombardi of SFStandard.com reports. | |
| Deebo Samuel Sr. | WR | Samuel (hamstring) has a chance to return following the 49ers' Week 8 bye, Matt Maiocco of NBC Sports Bay Area reports. | |
| Nick Bosa | DE | San Francisco head coach Kyle Shanahan said Monday that Bosa (knee) "has a chance" to return to action Nov. 8 versus the Raiders following a Week 8 bye, David Lombardi of SFStandard.com reports. | |
| Upton Stout | CB | Stout (shoulder) was only active as an emergency depth option during Sunday's loss to the Falcons, David Lombardi of SFStandard.com reported Monday. | |
| Luke Gifford | LB | questionable | |
| Garret Wallow | LB | questionable | |
| Marques Sigle | S | questionable | |
| 2026-10-19 | Brett Toth | C | Questionable |
| 2026-10-12 | Nick Martin | LB | Injured Reserve |
| 2026-09-23 | C.J. West | DT | Injured Reserve |
| 2026-09-21 | Brandon Aiyuk | WR | Out |
| 2026-09-16 | Jake Tonges | TE | Injured Reserve |
| 2026-09-10 | Alfred Collins | DT | Injured Reserve |
| 2026-09-08 | Nate Hobbs | CB | Injured Reserve |
| 2026-09-07 | Sam Okuayinonu | DT | Injured Reserve |
| 2026-08-31 | |||
| Nick Zakelj | OT | Injured Reserve | |
| Austen Pleasants | OT | Injured Reserve | |
| 2026-08-30 | Isaac Guerendo | RB | Out |
| 2026-08-13 | Ricky Pearsall | WR | Injured Reserve |
| 2026-08-03 | Mikail Kamara | DE | Injured Reserve |
| 2026-07-30 | Andrew Farmer II | DE | Injured Reserve |
| 2026-05-28 | Darrick Forrest | S | Injured Reserve |