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As the 2026 NFL season approaches Week 5, teams have released their final injury reports ahead of Sunday's games. Injuries have already taken a toll this season, with star players frequently sidelined, forcing teams to adjust their strategies. This week, Bears quarterback Caleb Williams is questionable and could return, while quarterback Jayden Daniels is cleared to play. The Chiefs and Panthers are on bye, allowing them to heal for Week 6.
Philadelphia Eagles at Jacksonville Jaguars (-7) in London
The Eagles will be without star running back Saquon Barkley (hamstring), who was injured in last week's loss to the Rams. Wide receiver DeVonta Smith (hamstring) is also out, along with wide receiver Marquise Brown (ankle), center Drew Kendall (knee), and safety Marcus Epps (groin). Outside linebacker Jonathan Greenard (ankle) is questionable. The Jaguars are relatively healthy, with cornerback Jaylon Jones (hamstring) out and safety Eric Murray (concussion) doubtful.
Chicago Bears at Green Bay Packers (-2.5)
Bears quarterback Caleb Williams (hamstring) is questionable after missing two weeks. He was limited in Friday's practice after not practicing Wednesday or Thursday. Running back Kyle Monangai (thumb/toe) and linebacker Keyshaun Elliott (quad) are out. The Packers will be without running back Chris Brooks (ankle) and wide receiver Savion Williams (ankle). Guard Aaron Banks (knee/toe) and offensive lineman Jacob Monk (quad) are doubtful. Defensive tackle Javon Hargrave (toe) is questionable. Running back Pierre Strong will play his first game since 2024.
Houston Texans (-7.5) at Tennessee Titans
Texans wide receiver Tank Dell (knee) is out, but the team activated his 21-day window to return from IR. The Texans have several questionable players due to illness and minor injuries. The Titans will be without safety Amani Hooker (concussion). Wide receiver Carnell Tate (back) is questionable, but head coach Robert Saleh said he would be good to go.
Cincinnati Bengals (-6.5) at Miami Dolphins
Bengals safety Kyle Dugger (quad) is out. Wide receivers Ja'Marr Chase (concussion) and Tee Higgins (groin/neck) are questionable, but both were full participants on Friday. The Dolphins have multiple players out, including wide receiver Caleb Douglas (ankle), tight end Justin Joly (concussion), edge rusher Robert Beal Jr. (hamstring), and cornerback Reese Taylor (quad). Running back Jaylen Wright (foot), defensive lineman Kenneth Grant (toe), linebacker Jackson Woodard (ankle), and cornerback Storm Duck (knee) are questionable.
Las Vegas Raiders at New England Patriots (-3.5)
Raiders running back Ashton Jeanty (hamstring) is questionable after not practicing Friday. Tight end Brock Bowers (knee) has no game designation. The Patriots will be without top cornerback Christian Gonzalez (shoulder) and cornerback Carlton Davis (neck). Defensive tackle Christian Barmore (shoulder) is questionable. Wide receiver Mack Hollins (calf) is out, further depleting the offense.
Minnesota Vikings (-1.5) at New Orleans Saints
Vikings wide receiver Justin Jefferson (ankle) is questionable after being limited all week. Wide receiver Jordan Addison (hamstring) is also questionable. The Saints have three players out and three questionable, including running back Alvin Kamara (back).
Cleveland Browns at New York Jets (-1.5)
All Browns players with game designations are out, including quarterback Dillon Gabriel (back) and defensive tackle Mason Graham (knee/ankle). The Jets will be without running back Breece Hall (quad) and wide receiver Adonai Mitchell (finger). Edge rushers Kingsley Enagbare (knee) and Will McDonald IV (calf) are questionable.
Indianapolis Colts at Pittsburgh Steelers (-2.5)
Colts wide receiver Keenan Allen (groin) is questionable but was a full participant Friday. Wide receiver Darius Slayton (knee) is also questionable. The Steelers will be without wide receiver Michael Pittman (foot), cornerback Jamel Dean (ankle), and safety DeShon Elliott (knee). Running back Rico Dowdle (toe) and cornerback Jalen Ramsey (wrist) are questionable.
New York Giants at Washington Commanders (-3.5)
The Giants are healthy, with two players out. The Commanders will have quarterback Jayden Daniels, but six players are out, including wide receiver Stefon Diggs (hamstring). Wide receiver Terry McLaurin (hamstring) is questionable; coach Dan Quinn said he looked really good but didn't confirm his status.
Denver Broncos (-3.5) at Los Angeles Chargers
The Broncos are healthy, with cornerback Patrick Surtain II (ankle) out. The Chargers have a lengthy injury report, with wide receivers Quentin Johnston (chest) and Brenen Thompson (quad), offensive tackle Joe Alt (neck), guard Kayode Awosika, offensive lineman Trevor Penning (concussion), cornerback Donte Jackson (hamstring), and safety Derwin James (hamstring) out. Quarterback Trey Lance (groin) is doubtful. Wide receiver Ladd McConkey (foot) is questionable after not practicing all week.
Detroit Lions (-5.5) at Arizona Cardinals
The Lions ruled out guard Ben Bartch (foot), center Cade Mays (wrist), cornerback Rock Ya-Sin (hamstring), and safety Brian Branch (Achilles). Defensive lineman Tyleik Williams (foot) is questionable. The Cardinals have two players out and two questionable, including defensive lineman Walter Nolen (calf).
San Francisco 49ers at Seattle Seahawks (-2.5)
The 49ers will be without defensive end Nick Bosa (knee/calf) and fullback Kyle Juszczyk (knee), among others. Cornerback Upton Stout (shoulder) and defensive end Mykel Williams (knee) are questionable. The Seahawks ruled out running back Zach Charbonnet (knee), cornerback Julian Neal (hamstring), and linebacker Chazz Surratt (calf).
Baltimore Ravens at Atlanta Falcons (-3.5)
Ravens quarterback Lamar Jackson (ankle) is out, a major blow to the offense. Center Cam Jurgens (concussion) and outside linebacker Trey Hendrickson (finger) are also out. Wide receiver Zay Flowers (foot), guard Andrew Vorhees (foot), and cornerback Marlon Humphrey (hamstring/calf) are questionable. The Falcons will be without linebacker Yasir Abdullah (hamstring). Left tackle Jake Matthews (groin), defensive end Samson Ebukam (hamstring), defensive end Za'Darius Smith (concussion/neck), and linebacker Divine Deablo (hamstring) are questionable.
Originally reported by cbssports.