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Former NFL All-Pro Marcellus Wiley was arrested on a domestic battery charge in Florida on Saturday, according to TMZ.
Wiley was booked into the Orange County Jail over the holiday weekend, the outlet reports.
He is being held without bond, according to custody records TMZ viewed.
No details have been released about what led to his arrest.
Wiley was a defensive lineman in the NFL from 1997 to 2006.
He was drafted by the Buffalo Bills in the second round of the 1997 NFL Draft out of Columbia University.
Wiley played for the Buffalo Bills, San Diego Chargers, Dallas Cowboys and Jacksonville Jaguars during his NFL career.
He was a second-team All-Pro in 2001 when he recorded 13 sacks and five forced fumbles for the Chargers.
The California native, who said earlier this year that he could get into politics, appeared in 147 NFL games, making 79 starts, across his 10 seasons in the NFL.
He finished his NFL career with 321 tackles, 44 sacks and 13 forced fumbles.
He went on to work as a football analyst at ESPN and FS1 following his playing days.
Wiley currently has a YouTube channel -- Marcellus Wiley Dat Dude TV -- that has 563,000 subscribers.
His most recent video was posted July 3.